Week 1: September 6 - September 12
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| THU, SEP 7 | TIME (ET) | TV | TICKETS | LOCATION |
| Kansas City at New England | 8:30 PM | NBC | Gillette Stadium | |
| SUN, SEP 10 | TIME (ET) | TV | TICKETS | LOCATION |
| NY Jets at Buffalo | 1:00 PM | CBS | New Era Field | |
| Atlanta at Chicago | 1:00 PM | FOX | Soldier Field | |
| Baltimore at Cincinnati | 1:00 PM | CBS | Paul Brown Stadium | |
| Pittsburgh at Cleveland | 1:00 PM | CBS | FirstEnergy Stadium | |
| Arizona at Detroit | 1:00 PM | FOX | Ford Field | |
| Jacksonville at Houston | 1:00 PM | CBS | NRG Stadium | |
| Tampa Bay at Miami | 1:00 PM | FOX | Hard Rock Stadium | |
| Oakland at Tennessee | 1:00 PM | CBS | Nissan Stadium | |
| Philadelphia at Washington | 1:00 PM | FOX | FedEx Field | |
| Indianapolis at Los Angeles | 4:05 PM | CBS | Los Angeles Memorial Coliseum | |
| Seattle at Green Bay | 4:25 PM | FOX | Lambeau Field | |
| Carolina at San Francisco | 4:25 PM | FOX | Levi's Stadium | |
| NY Giants at Dallas | 8:30 PM | NBC | AT&T Stadium | |
| MON, SEP 11 | TIME (ET) | TV | TICKETS | LOCATION |
| New Orleans at Minnesota | 7:10 PM |   | U.S. Bank Stadium | |
| Los Angeles at Denver | 10:20 PM | | Sports Authority Field at Mile High | |
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